Synechocystis sp. PCC6803 : slr2143

ORF IDslr2143
Gene name
DefinitionL-cysteine/cystine C-S-lyase (C-DES)
Position1271069..1272274    
Length401 aa
1206 bp   +upstreambp   +downstreambp
CyanoBaseslr2143 L-cysteine/cystine lyase
UniProtP73679 Isopenicillin N epimerase.
KOK11325 K11325; L-cysteine/cystine lyase
Pfam / Prositepf:Aminotran_1_2
pf:Aminotran_5
pf:DegT_DnrJ_EryC1
pf:Beta_elim_lyase
ps:AA_TRANSFER_CLASS_5
Ortholog    
Paralog  

Commentcrystal structure: PDB code ELQ (native c-DES) and ELU (product complexed c-DES)
Remark
Mutant
Category
Reference
1. Lang T, Kessler D (1999) Evidence for cysteine persulfide as reaction product of L-Cyst(e)ineC-S-lyase (C-DES) from Synechocystis. Analyses using cystine analogues andrecombinant C-DES. J Biol Chem 274:189-95 [PMID:9867829]
2. Clausen T, Kaiser JT, Steegborn C, Huber R, Kessler D (2000) Crystal structure of the cystine C-S lyase from Synechocystis: stabilization of cysteine persulfide for FeS cluster biosynthesis. Proc Natl Acad Sci U S A 97:3856-61. [PMID:10760256]
3. Kaiser JT, Bruno S, Clausen T, Huber R, Schiaretti F, Mozzarelli A, Kessler D (2003) Snapshots of the cystine lyase C-DES during catalysis. Studies in solution and in the crystalline state. J Biol Chem 278:357-65. [PMID:12386155]
PubMed search
Homology BLAST     FASTA
3D Structure PDB     GTOP
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